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KMID : 0377220020270020033
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Medical Journal of Chosun Univercity
2002 Volume.27 No. 2 p.33 ~ p.41
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Association of cyclin E, bcl-2, p27, VEGF, p53 and E-cadherin expression in cervical intraepithelial neoplasia and squamous cell carcinoma
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Suh Chae-Hong
Yang Jeong-Won
Sung Jung-Hee
Oh Soo-Sup
Lee Mi-Ja
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Abstract
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Background and Objectives: Correlation of cyclin E, bcl-2, p27, VEGF, p53 and E-cadherin expression was analyzed in cervical intraepithelial neoplasia (CIN), carcinoma in situ (CIS), and microinvasive and invasive squamous cell carcinoma (SCC) according to human papilloma virus (HPV) inffection.
Materials and Methods : (23 CIN 1, 28 CIN 2, 23 CIN 3), 18 CIS, and 24 SCC.
Results: Expression of cyclin E was significantly higher in CIN 2, CIN 3, CIS and SCC than CIN 1 with or without HPV infection. Expression of bcl-2 was significantly higher in CIN 3 than SCC. There was no association between expression of p27 and VEGF and progression of CIN 1 to SCC. Expression of p53 was significantly high in CIN 3, CIS and SCC with or without HPV infection. Expression of the E-cadherin was significantly high in CIN 2, CIN 3, CIS and SCC with or without HPV infection.
Conclusion: There was correlation between expression of cyclin E, b치-2, ㅔ53, E-cadherin and progression of CIN to SCC. It is suggested that cyclin E may play an important role in the neoplastic transformation of cervical squamous cell.
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KEYWORD
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Cervical intraepithelial neoplasia, Squamous cell carcinoma, Cyclin E, CDK inhibitor p27, VEGF, E-cadherin
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